3-Mercaptopyruvate sulfurtransferase disruption in dermal fibroblasts facilitates adipogenic trans-differentiation
نویسندگان
چکیده
منابع مشابه
Expression of 3-Mercaptopyruvate Sulfurtransferase in the Mouse.
3-Mercaptopyruvate sulfurtransferase (MST) is one of the principal enzymes for the production of hydrogen sulfide and polysulfides in mammalians, and emerging evidence supports the physiological significance of MST. As a fundamental study of the physiology and pathobiology of MST, it is necessary to establish the tissue distribution of MST in mice. In the present study, the expression of MST in...
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3-mercaptopyruvate sulfurtransferase (MST) is a universal enzyme in prokaryotes and eukaryotes. In 1998, we reported the distribution of MST in rat [1]. MST was expressed in numerous somatic cells and was found to be present in both cytosol and mitochondria [1] (Figure 1a). In the kidney, MST levels were higher in the cortex and proximal convoluted tubules as compared to that in the medulla and...
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Rosiglitazone (RSG) is a potent drug used in the treatment of insulin resistance; however, it is associated with marked skeletal toxicity. RSG-induced osteoporosis may contribute to the promotion of adipogenic differentiation at the expense of osteogenic differentiation in bone marrow stromal cells. The aim of this study was to investigate whether RSG-induced bone toxicity can be reversed by co...
متن کاملHuman dermal fibroblasts exhibit delayed adipogenic differentiation compared with mesenchymal stem cells.
Human dermal fibroblasts (FBs) express mesenchymal stem cell (MSC)-specific cell surface markers and differentiate into several cell types under appropriate conditions. Molecular mechanisms controlling the early stages of differentiation of dermal FBs and MSCs isolated from different sources have not been well studied. Here, we have analyzed the cell type-specific changes of adipose tissue-deri...
متن کاملIdentification of H2S3 and H2S produced by 3-mercaptopyruvate sulfurtransferase in the brain
Hydrogen polysulfides (H2Sn) have a higher number of sulfane sulfur atoms than hydrogen sulfide (H2S), which has various physiological roles. We recently found H2Sn in the brain. H2Sn induced some responses previously attributed to H2S but with much greater potency than H2S. However, the number of sulfur atoms in H2Sn and its producing enzyme were unknown. Here, we detected H2S3 and H2S, which ...
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ژورنال
عنوان ژورنال: Experimental Cell Research
سال: 2019
ISSN: 0014-4827
DOI: 10.1016/j.yexcr.2019.111683